I just today put an Acrylic gloss medium over one of my flower paintings. The painting is on 300 lb. hot press paper, which has one coat gesso, than painted over that with Acrylic paints. I let it dry overnight before coating. The medium is water based and I added a little bit of burnt umber to it. Has nice shine which I like. Too me this is all in the family and should have no reaction of any kind. I don't plan to put in glass over it.
THIS HELPED ME SO MUCH! I'm a beginner painter, this answered my question perfectly! Thank you so much :)